PhD research: Depressed Skull fractures: Timing of surgery, systemic inflammatory response, surgical site infection, and post-traumatic seizures - (DESTINE Study)

October 2021 to September 2026
depressed skull fracture
timing of surgery
systemic inflammatory responses
surgical site infection
post-traumatic epilepsy
Makerere University (Uganda)
Research fields
Medicine and Health Sciences

The timing for surgery of depressed skull fracture (DSF) in low-income-countries remains unclear due to the risks from the intraoperative bleeding versus surgical site infection. Neuro-inflammation induced by trauma, anaesthesia, and surgery stress predispose patients to late post-traumatic epilepsy. Indepth immunological, imaging, and clinical studies of patients with DSF could improve the understanding and decision-making of the surgical timing.